gene 2,575 words KG: SCRIB
Contents

SCRIB Gene

🧬 Gene Info
Gene SymbolSCRIB
Full NameScribble Planar Cell Polarity Protein
AliasesScribble
Chromosome8q24.3
Functionencodes a protein of 1,757 amino acids with a molecular weight of approximately 220 kDa.
Primary ExpressionBrain (cortex, hippocampus, cerebellum), epithelial tissues
Molecular Weight220 kDa
Amino Acids1757 aa
Exons34
PathwaysAutophagy, Inflammasome, Phagocytosis
UniProt IDQ14160
NCBI Gene ID23513
Ensembl IDENSG00000103067
OMIM607584
GeneCardsSCRIB
Human Protein AtlasSCRIB
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsAUTOPHAGY, MICROGLIA, NEURON, NLRP3, PARKINSON, ROS
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Related Hypotheses (114)

CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
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R-Loop Resolution Enhancement Therapy
Score: 0.68
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Complement C1q Subtype Switching
Score: 0.66
RNA Granule Nucleation Site Modulation
Score: 0.66
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Microbial Inflammasome Priming Prevention
Score: 0.65
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Oligodendrocyte White Matter Vulnerability
Score: 0.65
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
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Related Analyses (29)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (15)

Microglia
cell · KG edge: activates
Parkinson Basal Ganglia Circuit
circuit · KG edge: activates
NeuRon Therapeutics
company · KG edge: activates
Neurodegeneration
disease · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: co_discussed

Knowledge Graph (12 edges)

BAK1 co_discussed SCRIB
BAX co_discussed SCRIB
BID co_discussed SCRIB
MTOR co_discussed SCRIB
BDNF co_discussed SCRIB
FGF21 co_discussed SCRIB
HEPSIN co_discussed SCRIB
SCRIB co_discussed STING
APC co_discussed SCRIB
APP co_discussed SCRIB

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