gene 625 words KG: RGS5
Contents

RGS5 — Regulator of G Protein Signaling 5

🧬 Gene Info
Gene SymbolRGS5
Full NameRegulator of G Protein Signaling 5
Chromosome1q23.3
FunctionBy accelerating GTP hydrolysis on Gαq subunits, RGS5 terminates signaling from vasoconstrictor receptors including angiotensin II (AT1R), endothelin-1 (ETA), and α1-adrenergic receptors.
Primary ExpressionVascular smooth muscle cells, Pericytes, Brain vasculature
Amino Acids177 aa
UniProt IDQ9NZH6
NCBI Gene ID6053
Ensembl IDENSG00000143248
OMIM607073
GeneCardsRGS5
Human Protein AtlasRGS5
InteractionsCRH, EPILEPSY, INFLAMMATION, PDGFRB, PENK, SST
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Purinergic Signaling Polarization Control
Score: 0.71
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (7)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

See Also (9)

NeuRon Therapeutics
company · KG edge: inhibits
Neurodegeneration
disease · KG edge: implicated_in
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: associated_with
CRH Gene
gene · KG edge: inhibits
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: activates

Knowledge Graph (12 edges)

RGS5 activates PDGFRB
CRH inhibits RGS5
PVALB associated_with RGS5
SST inhibits RGS5
RGS5 inhibits PENK
RGS5 expressed_in PVALB
RGS5 inhibits SST
PENK inhibits RGS5
RGS5 expressed_in pericytes
COL1A1 associated_with RGS5

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