gene 513 words KG: PDK3
Contents

PDK3 - 3-Phosphoinositide-Dependent Protein Kinase-3

🧬 Gene Info
Gene SymbolPDK3
Full Name3-Phosphoinositide-Dependent Protein Kinase-3
AliasesPage for PDK3
ChromosomeXp22.11
Protein TypeKinase
Functionencodes a member of the phosphoinositide-dependent protein kinase (PDK) family.
Primary Expressionvarious tissues, with high expression in brain, and is implicated in neurodegenerative diseases and cancer
Molecular Weight39 kDa
Amino Acids350 aa
PathwaysPI3K, mTOR Pathway, AMPK Pathway, MAPK Pathway
UniProt IDO95819
NCBI Gene ID5165
Ensembl IDENSG00000168268
OMIM300341
GeneCardsPDK3
Human Protein AtlasPDK3
Associated Diseasesneurodegeneration
InteractionsAND, CANCER, C-MYC, E2F1, ENO1, GENES
KG Connections24 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

APOE-Dependent Autophagy Restoration
Score: 0.86
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (11)

Neurodegeneration
disease · KG edge: implicated_in
Genes
index · KG edge: activates
E2F1 Gene
gene · KG edge: activates
ENO1 Gene
gene · KG edge: activates
HK2
gene · KG edge: activates

Knowledge Graph (12 edges)

E2F1 activates PDK3
ENO1 activates PDK3
PDK3 activates HK2
PDK3 activates PDK1
PDK3 activates MYC
PDK3 activates Mitosis
MYC activates PDK3
RB1 associated_with PDK3
NBEA associated_with PDK3
PDK3 activates CANCER

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