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gene 1,319 words KG: LRP4
Contents

LRP4 — Low Density Lipoprotein Receptor-Related Protein 4

🧬 Gene Info
Gene SymbolLRP4
Full NameLow Density Lipoprotein Receptor-Related Protein 4
AliasesPage for LRP4 Protein
Chromosome11p11.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight195 kDa
Amino Acids1725 aa
Exons33
PathwaysWnt signaling, Wnt
UniProt ID[Q9NPJ6](https://www.uniprot.org/uniprot/Q9NPJ6)
Ensembl IDENSG00000134538
GeneCardsLRP4
Human Protein AtlasLRP4
Associated DiseasesAging, Als, Atherosclerosis, Cancer, Cardiovascular
InteractionsCANCER, PAH, WNT
KG Connections68 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedPerivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (9)

CD4 Gene
gene · KG edge: therapeutic_targetLDLR Gene
gene · KG edge: associated_withLRP1B — Low Density Lipoprotein Receptor-Related Protei
gene · KG edge: associated_withLRP2 — Low Density Lipoprotein Receptor-Related Protein
gene · KG edge: associated_withAutoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: therapeutic_target

Knowledge Graph (12 edges)

LRP8 associated_with LRP4
LRP5 associated_with LRP4
LRP1 associated_with LRP4
LRP2 associated_with LRP4
LRP1B associated_with LRP4
LRP4 associated_with PAH
LRP4 associated_with LDLR
PAH associated_with LRP4
LRP4 associated_with LRP5
LRP4 associated_with LRP1

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