gene 509 words KG: JAM2
Contents

JAM2 - Junctional Adhesion Molecule 2

🧬 Gene Info
Gene SymbolJAM2
Full NameJunctional Adhesion Molecule 2
AliasesPage for JAM2
FunctionJAM2 mediates homophilic (JAM2-JAM2) and heterophilic (JAM2-JAM3) interactions at cell junctions
Primary Expressionbrain endothelial cells forming the blood-brain barrier, with lower expression in neurons (particularly in the [hippocampus](/bra
Ensembl IDENSG00000176182
GeneCardsJAM2
Human Protein AtlasJAM2
Associated DiseasesAging, Als, Ataxia, Ms, Parkinson
InteractionsCMPK2, MYORG, PDGFB, PDGFRB, SLC20A2, XPR1
KG Connections43 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (9)

Cerebellum
brain · KG edge: expressed_in
Parkinson Basal Ganglia Circuit
circuit · KG edge: associated_with
Genes
index · KG edge: associated_with
JUN Gene
gene · KG edge: associated_with
OCLN — Occludin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

JUN associated_with JAM2
JAM2 associated_with PDGFB
JAM2 associated_with OCLN
JAM2 associated_with JUN
PDGFB associated_with JAM2
JAM2 associated_with Primary Familial Brain Calcification
PDGFRB associated_with JAM2
PDGFRB interacts_with JAM2
JAM2 interacts_with PDGFB
JAM2 associated_with Rb

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