Contents

PLP1 Gene

🧬 Gene Info

Gene Symbol	PLP1
Protein Family	Proteolipid protein family
Function	PLP1 is essential for multiple aspects of CNS myelination:
Primary Expression	CNS (not PNS)
Subcellular Localization	Myelin sheath, oligodendrocyte plasma membrane
Molecular Weight	30 kDa
Amino Acids	35 aa
Pathways	Phagocytosis
UniProt ID	[P60228](https://www.uniprot.org/uniprot/P60228)
GeneCards	PLP1
Human Protein Atlas	PLP1
Prenatal	Low expression in oligodendrocyte progenitor cells
Postnatal	Dramatic increase during active myelination (first 3-6 months in humans)
Adult	Sustained expression for myelin maintenance
Regional	Highest expression in cerebral white matter, corpus callosum, internal capsule, and spinal cord
Associated Diseases	ALS, Alzheimer, dementia, Ms, myelin dysfunction, Parkinson
Known Drugs/Compounds	CURCUMIN, RESVERATROL
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND, APOE, App
KG Connections	207 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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