gene 1,588 words KG: FXN
Contents

FXN — Frataxin

🧬 Gene Info
Gene SymbolFXN
Full NameFrataxin
Chromosome9q21.11
FunctionWithin this complex, frataxin
Primary ExpressionDorsal root ganglia, Spinal cord, Cerebellum, Heart, Pancreas, Liver
Molecular Weight14 kDa
Amino Acids210 aa
PathwaysAutophagy, Mitophagy
UniProt IDQ16595
Ensembl IDENSG00000165060
OMIM606829
GeneCardsFXN
Human Protein AtlasFXN
Associated DiseasesAtaxia, Friedreich's Ataxia, Migraine
InteractionsAND, C-MYC, HMOX1, MITOCHONDRIA, MYC, NAD
KG Connections63 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.94
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61

Related Analyses (2)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
BNIP3 Gene
gene · KG edge: regulates
PPP3CA — Protein Phosphatase 3 Catalytic Subunit Alpha
gene · KG edge: regulates
CDK4 Gene
gene · KG edge: associated_with
CHD4 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

KCNK5 associated_with FXN
TGFB1 associated_with FXN
TP53 associated_with FXN
NR1D1 associated_with FXN
FXN associated_with EPHA5
FXN associated_with EP300
FXN associated_with NLGN2
FXN associated_with CDK4
FXN associated_with CHD4
FXN associated_with HMGCR

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