gene 1,920 words KG: FUS
Contents

FUS — Fused in Sarcoma

🧬 Gene Info
Gene SymbolFUS
Full NameFused in Sarcoma
Chromosome16p11.2.
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysBlood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43
UniProt IDSearch UniProt
GeneCardsFUS
Human Protein AtlasFUS
Associated DiseasesAD, Aging, ALI, Als, ALS/FTD
Known Drugs/CompoundsADUCANUMAB, Antisense Oligonucleotide, Rna Oligonucleotides, RNA oligonucleotides
InteractionsACTB, Actin, AD, AGING, ALPHA-SYNUCLEIN, ALS
SciDEX HypothesesASO-Mediated Exon Skipping to Restore FUS-TAZ Chap
FUS Phase Separation Dominance in FTD-TDP: Aberran
Arginine Methylation Loss on FUS RGG Domains Drive (+6 more)
KG Connections1549 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (44)

Axonal RNA Transport Reconstitution
Score: 0.70
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
← Prevpg 3/3

Related Analyses (11)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (4)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40

See Also (8)

ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCD3 Gene
gene · KG edge: interacts_with
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibits
ACTB Gene
gene · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: activates

Knowledge Graph (12 edges)

ACTB interacts_with FUS
OPTN interacts_with FUS
ULK1 interacts_with FUS
SMCR8 interacts_with FUS
CALCOCO2 interacts_with FUS
LC3 interacts_with FUS
BECN1 interacts_with FUS
C9ORF72 interacts_with FUS
NBR1 interacts_with FUS
G3BP1 interacts_with FUS

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