gene 1,686 words KG: DLAT
Contents

DLAT Gene

🧬 Gene Info
Gene SymbolDLAT
Full NameDihydrolipoamide S-Acetyltransferase
Chromosome11q23.1
FunctionDLAT is the central structural and catalytic component of the pyruvate dehydrogenase complex, forming a 24-mer cubic core that organizes the entire complex[@patel2014]
PathwaysAkt, Apoptosis, Immune Response, Pi3K/Akt, apoptosis
UniProt ID[P10515](https://www.uniprot.org/uniprot/P10515)
Ensembl IDENSG00000150768
OMIM608770
GeneCardsDLAT
Human Protein AtlasDLAT
Lipoic acid synthesisDe novo creation of the dithiolane ring
Associated DiseasesAlzheimer's disease
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND, APOPTOSIS
KG Connections69 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (17)

CYP46A1 Overexpression Gene Therapy
Score: 0.98
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Circadian Clock-Autophagy Synchronization
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ATF3 Gene
gene · KG edge: activates
BAX Gene
gene · KG edge: activates
BDNF Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

AKT activates DLAT
SLC31A1 activates DLAT
PER2 activates DLAT
HSP70 activates DLAT
CLOCK activates DLAT
ATF3 activates DLAT
DLAT associated_with copper
DLAT regulates CaMKII
DLAT activates JAK2
DLAT activates STAT5A

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