| Gene Symbol | CSNK2B |
| Protein Type | Enzyme |
| Function | CSNK2B encodes the beta subunit of casein kinase 2 (CK2), a serine/threonine protein kinase with diverse cellular functions. |
| Primary Expression | neurons and glial cells, with particularly high levels in the hippocampus and cerebral [cortex](/br |
| Pathways | Wnt, PI3K, NF-κB |
| Ensembl ID | ENSG00000101290 |
| GeneCards | CSNK2B |
| Human Protein Atlas | CSNK2B |
| Protein Phosphorylation | CK2 phosphorylates over 500 substrates involved in transcription, translation, cell cycle, and signal transduction [@casein2014] |
| Signal Transduction | Modulates numerous signaling pathways including Wnt, PI3K/Akt, and NF-κB [@nfb] |
| Transcriptional Regulation | Controls gene expression through phosphorylation of transcription factors and chromatin proteins [@transcription2013] |
| DNA Repair | Involved in DNA damage response and repair pathways [@dna2015] |
| Synaptic Function | Regulates synaptic plasticity and neurotransmitter receptor trafficking [@synaptic2008] |
| Parkinson's Disease | CK2 has been shown to phosphorylate alpha-synuclein, potentially influencing its aggregation properties. Research suggests CK2 may play a role in PD pathogenesis [@phosphorylation] |
| Huntington's Disease | CK2 activity is altered in HD models, affecting mutant huntingtin aggregation and toxicity [@huntingtons] |
| Associated Diseases | neurodegeneration |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!