Contents

ULK1 — UNC-51 Like Kinase 1

🧬 Gene Info

Gene Symbol	ULK1
Full Name	UNC-51 Like Kinase 1
Chromosome	2q24
Protein Family	Ser/Thr kinase (ULK family)
Protein Type	Kinase
Target Class	Kinase
Function	ULK1 is the initiating kinase for autophagy
Mechanism of Action	Small molecule activators or inhibitors of ULK1 kinase activity to modulate autophagy
Subcellular Localization	Cytoplasm, autophagosome
Druggability	Low (0.42)
Clinical Stage	Phase I
Molecular Weight	~1,050 amino acids (~112 kDa)
Amino Acids	050 aa
Pathways	AUTOPHAGY, Autophagy, Cell Cycle, Chaperone, Differentiation
UniProt ID	Q8N448
GeneCards	ULK1
Human Protein Atlas	ULK1
Associated Diseases	AD, Aging, ALI, Als, ALZHEIMER
Known Drugs/Compounds	ALT001, echinacoside, metformin, rapamycin, RAPAMYCIN, Shikonin
Interactions	14-3-3, 4E-BP1, ABCA1, ABCG1, ACAT1, ACC
SciDEX Target	View Target Profile (1 clinical trials)
SciDEX Hypotheses	TFEB-Independent Autophagy Bypass
KG Connections	2417 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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Knowledge Graph

CLOCK interacts_with ULK1

ULK1 interacts_with CLOCK

CLOCK co_discussed ULK1

CRH co_discussed ULK1

BDNF co_discussed ULK1

TREM2 co_discussed ULK1

FOXP3 co_discussed ULK1

TNFA co_discussed ULK1

PPARGC1A co_discussed ULK1