gene 1,077 words KG: ent-gene-d4ef6b3a
Contents

ASAH1 — N-Acylsphingosine Amidohydrolase 1

🧬 Gene Info
Gene SymbolASAH1
Full NameN-Acylsphingosine Amidohydrolase 1
Chromosome8p22
Protein TypeEnzyme
Functionis a lysosomal enzyme that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids.
Molecular Weight~44 kDa (precursor), ~13+20 kDa (processed)
Amino Acids395 aa
Exons16
PathwaysSphingolipid
UniProt ID[Q13510](https://www.uniprot.org/uniprot/Q13510)
Ensembl IDENSG00000104522
OMIM613468
GeneCardsASAH1
Human Protein AtlasASAH1
Associated DiseasesAging, Als, Ms, Parkinson, Parkinson's disease
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, , CERS2, CERS6
KG Connections70 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Sphingolipid Metabolism Reprogramming
Score: 0.62

Related Analyses (2)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (8)

Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
CERS2 — Ceramide Synthase 2 (Lass2)
gene · KG edge: activates
CERS6 Gene
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (2 edges)

ent-gene-d4ef6b3a data_in benchmark_ot_ad_answer_key:ASAH1
benchmark_ot_ad_answer_key:ASAH1 data_in ent-gene-d4ef6b3a

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