gene 696 words KG: CARD14
Contents

Caspase Recruitment Domain Family Member 14

🧬 Gene Info
Gene SymbolCARD14
Chromosome2q31.1
Functionis a gene encoding a member of the CARD family of that play critical roles in regulating cell death, inflammation, and immune signaling pathways[@jordan2012].
Primary Expressionskin keratinocytes and immune cells, but also shows expression in various tissues including the brain[@chang2018]
Molecular Weight125 kDa
PathwaysNF-κB, NF-κB signaling
UniProt IDQ9Y2K7
NCBI Gene ID15292
Ensembl IDENSG00000100916
GeneCardsCARD14
Human Protein AtlasCARD14
Associated Diseasesneurodegeneration
InteractionsAND, BCL2, MITOPHAGY, MYC, NF-ΚB, PLIN4
KG Connections20 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (13)

Neurodegeneration
disease · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: protects_against
Genes
index · KG edge: protects_against
BCL2 Gene
gene · KG edge: inhibits
BDNF Gene
gene · KG edge: protects_against

Knowledge Graph (12 edges)

TAU protects_against CARD14
FGF2 protects_against CARD14
PLIN4 inhibits CARD14
BDNF protects_against CARD14
BCL2 inhibits CARD14
CARD14 protects_against APP
CARD14 activates MYC
MITOPHAGY inhibits CARD14
NEURODEGENERATION protects_against CARD14
ALZHEIMER protects_against CARD14

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