gene 3,663 words KG: ATXN2
Contents

ATXN2 Gene

🧬 Gene Info
Gene SymbolATXN2
AliasesAtaxin-2
Chromosome12q24.12
FunctionTranslational regulation — Associates with actively translating polysomes
Molecular Weight140 kDa
Amino Acids318 aa
Exons32
PathwaysApoptosis, Autophagy
GeneCardsATXN2
Human Protein AtlasATXN2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, dementia
Known Drugs/CompoundsAntisense Oligonucleotides, levodopa, rapamycin
InteractionsALS, AND, ATP13A2, ATXN3, C9ORF72, DNA
SciDEX HypothesesAtaxin-2 Polyglutamine Expansions Hijack G3BP1 to
KG Connections326 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
← Prevpg 2/2

Related Analyses (8)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (7)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ATP13A2 — ATPase Cation Transporting 13A2
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates

Knowledge Graph (12 edges)

ATXN2 associated_with CACNA1A
ATXN2 associated_with CHAT
ATXN2 associated_with FERMT2
ATXN2 associated_with OPTN
ATXN2 associated_with ABCA1
ATXN2 associated_with DPM2
ATXN2 associated_with TBK1
ATXN2 therapeutic_target C9ORF72
CHAT associated_with ATXN2
ATXN2 activates LRRK2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.