| Gene Symbol | FBXO7 |
| Full Name | F-Box Protein 7 |
| Aliases | PARK15 |
| Chromosome | 22q12 |
| Function | is a substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex. |
| Molecular Weight | 57 kDa |
| Amino Acids | 524 aa |
| Pathways | mTOR, NF-κB, Wnt |
| GeneCards | FBXO7 |
| Human Protein Atlas | FBXO7 |
| Ubiquitin-Interacting Motifs (UIM) | Located in the C-terminal region, these motifs bind to monoubiquitin and polyubiquitin chains, facilitating substrate recognition and chain assembly[^10]. |
| Proline-Rich Region | Mediates interactions with SH3 domain-containing proteins involved in signaling and cytoskeletal organization. |
| Dimerization Domain | Enables FBXO7 homodimerization, which may regulate its activity and substrate specificity[^11]. |
| Nuclear Localization Signals (NLS) | FBXO7 contains both nuclear import and export signals, enabling nucleocytoplasmic shuttling. |
| Associated Diseases | Als, Alzheimer, Cardiomyopathy, Cardiovascular, DOPAMINE |
| Interactions | AKT, ATP13A2, CHCHD2, CLPP, DJ1, DNAJC6 |
| KG Connections | 197 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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