disease 12,396 words KG: PSP
Contents

Progressive Supranuclear Palsy (PSP)

Disease Info
Globose neurofibrillary tanglesLocated in subcortical nuclei including the Subthalamic Nucleus (STN), Globus Pallidus (GP), substantia nigra (SN), and brainstem raphe nuclei[^7]
Tufted astrocytesAstrocytic inclusions specific to PSP, arranged in tufts around the nucleus
Coiled bodiesOligodendroglial inclusions in the white matter
Thread-like processesTau-positive neurites in the neuropil
Associated GenesABCA7, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, ATP13A2, BSN, C4A, CDKN2A
KG Connections343 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (21)

Microglial Purinergic Reprogramming
Score: 0.70
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Axonal RNA Transport Reconstitution
Score: 0.70
Oligodendrocyte White Matter Vulnerability
Score: 0.65
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
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Related Analyses (6)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (30)

PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40
Tau Spreading Network Mapping via Spatial Transcriptomics in
clinical · proposed · Score: 0.40
Tau Pathology Initiation Zone Identification
clinical · proposed · Score: 0.40

See Also (11)

Amyotrophic Lateral Sclerosis
redirect · KG edge: expressed_in
Frontotemporal Dementia (FTD)
disease · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: therapeutic_target
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

DUSP10 associated_with PSP
MAP1S associated_with PSP
PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
TAU activates PSP

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