concept

DHHC5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DHHC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

30Outgoing

11Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DHHC5
Key Genes/Proteins	Actin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, ATG14L
Related Diseases	Aging, Alzheimer, Alzheimer's disease, Hepatitis
Related Pathways	Apoptosis, autophagy pathway

Pathway Diagram

graph TD
    DHHC5["DHHC5"]
    DHHC5 -->|"modulates"| RIPK1["RIPK1"]
    DHHC5 -->|"catalyzes"| Palmitoylation["Palmitoylation"]
    DHHC5 -->|"mediates"| BECN1["BECN1"]
    DHHC5 -->|"regulates"| Autophagy["Autophagy"]
    DHHC5 -->|"inhibits"| Alzheimer["Alzheimer"]
    DHHC5 -->|"inhibits"| Aging["Aging"]
    DHHC5 -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    Aging -->|"downregulates"| DHHC5
    ALZHEIMER["ALZHEIMER"] -->|"inhibits"| DHHC5
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| DHHC5
    ATG14L["ATG14L"] -->|"activates"| DHHC5
    AGING["AGING"] -->|"inhibits"| DHHC5
    LYSOSOME["LYSOSOME"] -->|"inhibits"| DHHC5
    NEURODEGENERATION["NEURODEGENERATION"] -->|"inhibits"| DHHC5
    RIPK1 -->|"activates"| DHHC5

Outgoing (30)

Target	Relation	Type	Str
Autophagy	contributes_to	process	0.91
RIPK1	phosphorylates	protein	0.80
Hepatitis	activates	disease	0.65
Aging	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Tumor	activates	disease	0.65
Necroptosis	activates	disease	0.65
APOPTOSIS	activates	gene	0.60
RIPK1	activates	gene	0.60
TNF	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Actin	activates	protein	0.60
LYSOSOME	inhibits	gene	0.60
Neuron	inhibits	cell_type	0.60
AGING	inhibits	gene	0.60
ATG14L	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
Ras	activates	protein	0.60
Ubiquitin	activates	protein	0.60
RIPK1	interacts_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
autophagy pathway	participates_in	pathway	0.60
Alzheimer's disease	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
neurons	expressed_in	cell_type	0.60
necroptosis	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (11)

Source	Relation	Type	Str
Aging	downregulates	phenotype	0.93
RIPK1	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
TNF	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AUTOPHAGY	regulates	gene	0.60
ATG14L	activates	gene	0.60
AGING	inhibits	gene	0.60
LYSOSOME	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DHHC5 in their description or question text

No additional research found