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cell 916 words KG: DNA
Contents

DNA Damage-Accumulating Neurons in Neurodegeneration

🧫 Cell Type Info
Cell TypeDNA
Key PathwaysAMPK signaling, Adaptive Immunity, Akt, Amyloid, Angiogenesis
Associated DiseasesAD, ALI, ALS, AMI, ARM, Addiction
Related GenesCGAS, GENES
Linked Hypotheses721 hypotheses

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🌐 Cross-references

Wikipedia

Related Hypotheses (147)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74Senescent Cell Mitochondrial DNA Release
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74TREM2-mediated microglial tau clearance enhancement
Score: 0.62VCP-Mediated Autophagy Enhancement
Score: 0.59...
Score: 0.68
← Prevpg 8/8

Related Analyses (30)

What determines the specificity of DDR protein recruitment t
neurodegeneration · completedHow do dilncRNAs specifically drive molecular crowding and p
neurodegeneration · completedEpigenetic reprogramming in aging neurons
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Single-cell RNA-seq analysis of mouse testes with gonadal de
exploratory · completed · Score: 0.95cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95GWAS of plasma pTau217 in East Asian cohort
exploratory · proposed · Score: 0.95mtROS effects on TFAM and mtDNA in HK2 cells
exploratory · proposed · Score: 0.90TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 138 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 138 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 138 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 138 hypotheses

Knowledge Graph (12 edges)

DNA associated_with TDP-43
DNA associated_with neural stem cells
DNA associated_with neurons
DNA associated_with oligodendrocytes
DNA associated_with KRAS
DNA associated_with TP53
DNA associated_with PARKIN
DNA inhibits neural stem cells
DNA associated_with FUS
DNA associated_with PARP1

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