biomarker 2,458 words KG: CX3CL1
Contents

Fractalkine (CX3CL1) - Neuroinflammation Biomarker

🔬 Protein Info
Gene SymbolCX3CL1
Full NameFractalkine (C-X3-C Motif Chemokine Ligand 1)
AliasesC-X3-C Motif Chemokine Ligand 1
Chromosome16q13
Primary ExpressionNeurons (cortex, hippocampus), Endothelial cells, Dendritic cells
Amino Acids373 aa
PathwaysNeuroinflammatory
UniProt IDP78423
NCBI Gene ID6376
Ensembl IDENSG00000006210
OMIM601880
GeneCardsCX3CL1
Human Protein AtlasCX3CL1
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
InteractionsAGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections483 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (26)

TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
← Prevpg 2/2

Related Analyses (10)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (10)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - ALOX15 overexpression in healthy astrocytes should be
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · completed · Score: 0.40

Knowledge Graph (12 edges)

CX3CR1 therapeutic_target CX3CL1
CX3CL1 expressed_in OVERVIEW
CX3CL1 associated_with CXCR1
FGF21 activates CX3CL1
APP biomarker_for CX3CL1
FNDC5 activates CX3CL1
S100B biomarker_for CX3CL1
PLAU activates CX3CL1
CXCL10 activates CX3CL1
C1Q biomarker_for CX3CL1

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