Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PI3K_AKT_MTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| PROLIFERATION | regulates | phenotype | 0.72 |
| SURVIVAL | regulates | phenotype | 0.72 |
| METABOLISM | regulates | pathway | 0.72 |
| AUTOPHAGY_PATHWAY | regulates | pathway | 0.72 |
| PLURIPOTENCY | regulates | phenotype | 0.64 |
| SS | contributes_to | disease | 0.64 |
| DIFFERENTIATION | regulates | phenotype | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | participates_in | protein | 0.87 |
| GNETUPENDIN_A | activates | drug | 0.72 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR | 0.718 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PI3K_AKT_MTOR in their description or question text
No additional research found