gene 1,654 words KG: XPA
Contents

XPA Gene

🧬 Gene Info
Gene SymbolXPA
Full NameXPA DNA Repair Endonuclease
Chromosome9q34.3
FunctionXPA encodes a zinc-finger protein essential for nucleotide excision repair (NER).
Molecular Weight32 kDa
Amino Acids297 aa
PathwaysAutophagy, Circadian Rhythm, Mtor, Nf-Κb
UniProt IDP18077
NCBI Gene ID7508
Ensembl IDENSG00000136936
OMIM278700
GeneCardsXPA
Human Protein AtlasXPA
Associated Diseasesneurodegeneration
InteractionsAND, CLOCK, C-MYC, DNA, MYC, PDIA3
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Circadian Clock-Autophagy Synchronization
Score: 0.76
PARP1 Inhibition Therapy
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Neurodegeneration
disease · KG edge: implicated_in
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
BMAL1 (ARNTL) Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

MTOR regulates XPA
MYC activates XPA
XPA activates CLOCK
XPA activates PDIA3
XPA regulates BMAL1
XPA regulates AHR
AHR regulates XPA
BMAL1 regulates XPA
CLOCK activates XPA
XPA regulates MTOR

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