gene

IDH3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IDH3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

17Outgoing

6Incoming

0Experiments

0Debates

Summary

IDH3A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, regulates, implicated in. Associated with Als, Cardiac, Fibrosis. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IDH3A
Full Name	Isocitrate Dehydrogenase 3 Alpha
Chromosome	7q32.2
Protein Type	Enzyme
Function	is a critical mitochondrial enzyme in the tricarboxylic acid (TCA) cycle that plays a pivotal role in cellular energy metabolism.
Subcellular Localization	Mitochondrial matrix
Molecular Weight	46 kDa
Amino Acids	413 aa
Pathways	Autophagy, Histone Modification
GeneCards	IDH3A
Human Protein Atlas	IDH3A
Associated Diseases	neurodegeneration
Interactions	AND, APOPTOSIS, BCL-2, BNIP3, MITOPHAGY, NAD
KG Connections	23 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

idh3a

gene · 769 words

→

IDH3A Protein

protein · 791 words

→

Pathway Diagram

graph TD
    IDH3A["IDH3A"]
    Fibrosis{"Fibrosis"}
    IDH3A -->|"inhibits"| Fibrosis
    Als{"Als"}
    IDH3A -->|"inhibits"| Als
    Cardiac{"Cardiac"}
    IDH3A -->|"regulates"| Cardiac
    Ischemia{"Ischemia"}
    IDH3A -->|"regulates"| Ischemia
    Apoptosis(["Apoptosis"])
    IDH3A -->|"inhibits"| Apoptosis
    Autophagy(["Autophagy"])
    IDH3A -->|"regulates"| Autophagy
    Histone_Modification(["Histone Modification"])
    IDH3A -->|"regulates"| Histone_Modification
    Mitophagy(["Mitophagy"])
    IDH3A -->|"inhibits"| Mitophagy
    neurodegeneration["neurodegeneration"]
    IDH3A -->|"implicated in"| neurodegeneration
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| IDH3A
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"inhibits"| IDH3A
    TPM1["TPM1"]
    TPM1 -->|"inhibits"| IDH3A
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| IDH3A
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| IDH3A
    BCL_2["BCL-2"]
    BCL_2 -->|"inhibits"| IDH3A
    style IDH3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cardiac	regulates	disease	0.65
Ischemia	regulates	disease	0.65
AUTOPHAGY	regulates	gene	0.60
AND	inhibits	gene	0.60
GAIN	regulates	gene	0.60
TPM1	inhibits	gene	0.60
BNIP3	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
Autophagy	regulates	pathway	0.60
Histone Modification	regulates	pathway	0.60
MITOPHAGY	inhibits	gene	0.60
Mitophagy	inhibits	pathway	0.60
BCL-2	inhibits	gene	0.60
NAD	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60

Incoming (6)

Source	Relation	Type	Str
BNIP3	inhibits	gene	0.60
TPM1	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AUTOPHAGY	regulates	gene	0.60
BCL-2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IDH3A in their description or question text

No additional research found