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protein 616 words KG: TOMM70
Contents

TOMM70 Protein

🔬 Protein Info
Gene SymbolTOMM70
Protein FamilyTranslocase of outer mitochondrial membrane (TOM) complex
Protein TypeReceptor
Functionis a critical component of the mitochondrial outer membrane translocase complex (TOM), responsible for importing nearly all nuclear-encoded mitochondrial proteins[@nature2010].
Primary ExpressionMitochondrial outer membrane
Subcellular LocalizationMitochondrial outer membrane
Molecular Weight67 kDa
Amino Acids627 aa
PathwaysAutophagy, Mitophagy
UniProt IDQ9NS69
GeneCardsTOMM70
Human Protein AtlasTOMM70
Associated DiseasesAlzheimer
Known Drugs/CompoundsSpautin-1
InteractionsALZHEIMER, ALZHEIMER DISEASE, AND, AUTOPHAGY, BECN1, LYSOSOME
KG Connections39 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (11)

Mitochondria
entity · KG edge: activatesPINK1 (PTEN-Induced Kinase 1)
entity · KG edge: activatesAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activatesBECN1 Gene
gene · KG edge: activatesPIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subuni
gene · KG edge: activates

Knowledge Graph (12 edges)

PRKN activates TOMM70
PARL interacts_with TOMM70
BECN1 activates TOMM70
TOMM70 activates PIK3C3
TOMM70 interacts_with PINK1
TOMM70 interacts_with TOMM20
Spautin-1 binds TOMM70
PARL activates TOMM70
PINK1 activates TOMM70
TOMM20 activates TOMM70

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