Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNFSF12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TNF Superfamily Member 12 - cytokine mediating neuroinflammation, cell survival, and blood-brain barrier function
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| Gene Symbol | TNFSF12 |
| Full Name | TNFSF12 (TWEAK) |
| Aliases | TNF Superfamily Member 12 |
| Chromosome | 17p13.1 |
| Protein Type | Gene |
| Function | mediating neuroinflammation |
| Exons | 4 |
| Pathways | NF-κB, MAPK |
| GeneCards | TNFSF12 |
| Human Protein Atlas | TNFSF12 |
| Associated Diseases | Aging, Als, Dementia, Inflammation, Neurodegeneration, Neuroinflammation |
| Interactions | APOPTOSIS, STROKE, TNF |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TNFSF12["TNFSF12"]
TNF["TNF"]
AGGF1["AGGF1"]
IL6["IL-6"]
Neuroinflammation["Neuroinflammation"]
Apoptosis_pathway["Apoptosis"]
Differentiation["Differentiation"]
ALS["ALS"]
Dementia["Dementia"]
Stroke["Stroke"]
Aging["Aging"]
Neurodegeneration["Neurodegeneration"]
TNF -->|"activates"| TNFSF12
AGGF1 -->|"upregulates"| TNFSF12
IL6 -->|"associates with"| TNFSF12
TNFSF12 -->|"promotes"| Neuroinflammation
TNFSF12 -->|"activates"| Apoptosis_pathway
TNFSF12 -->|"therapeutic target"| Differentiation
TNFSF12 -->|"associated with"| ALS
TNFSF12 -->|"associated with"| Dementia
TNFSF12 -->|"activates"| Stroke
TNFSF12 -->|"associated with"| Aging
TNFSF12 -->|"associated with"| Neurodegeneration
Neuroinflammation -->|"contributes to"| Neurodegeneration
Apoptosis_pathway -->|"drives"| Neurodegeneration
style TNFSF12 fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
style Differentiation fill:#1b5e20
style TNF fill:#4a1a6b
style AGGF1 fill:#4a1a6b
style IL6 fill:#4a1a6b
style Neuroinflammation fill:#ef5350
style Apoptosis_pathway fill:#ef5350
style ALS fill:#7d4200
style Dementia fill:#7d4200
style Stroke fill:#7d4200
style Aging fill:#7d4200
style Neurodegeneration fill:#7d4200| Target | Relation | Type | Str |
|---|---|---|---|
| Atherosclerosis | therapeutic_target | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Neuroinflammation | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Stroke | activates | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Aging | biomarker_for | disease | 0.65 |
| Schizophrenia | biomarker_for | disease | 0.65 |
| Neurodegeneration | biomarker_for | disease | 0.65 |
| Differentiation | therapeutic_target | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| NEUROINFLAMMATION | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AGGF1 | upregulates | gene | 0.80 |
| ALS | associated_with | gene | 0.60 |
| STROKE | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| IL-18 | expressed_in | gene | 0.60 |
| CD68 | associated_with | gene | 0.60 |
| TBK1 | associated_with | gene | 0.60 |
| TBK1 | targets | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| DEMENTIA | associated_with | gene | 0.60 |
| IL-6 | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| TNF-Α | associated_with | gene | 0.60 |
| EGF | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TNFSF12 in their description or question text
No additional research found