concept

SYNAPTIC DYSFUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

5Hypotheses

2Analyses

11Outgoing

50Incoming

2Experiments

3Debates

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💡 Concept Info

Name	SYNAPTIC DYSFUNCTION

Pathway Diagram

graph TD
    SYNAPTIC_DYSFUNCTION["SYNAPTIC DYSFUNCTION"]
    SYNAPTIC_DYSFUNCTION -->|"contributes to"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    SYNAPTIC_DYSFUNCTION -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    C1q["C1q"] -->|"causes"| SYNAPTIC_DYSFUNCTION
    Sporadic_Alzheimer_s_Disease["Sporadic Alzheimer's Disease"] -->|"causes"| SYNAPTIC_DYSFUNCTION
    SOLUBLE_OLIGOMERS["SOLUBLE OLIGOMERS"] -->|"causes"| SYNAPTIC_DYSFUNCTION
    Calcium_Homeostasis["Calcium Homeostasis"] -->|"regulates"| SYNAPTIC_DYSFUNCTION
    aging["aging"] -->|"promotes"| SYNAPTIC_DYSFUNCTION
    Hdac__Class_I_["Hdac (Class I)"] -->|"contributes to"| SYNAPTIC_DYSFUNCTION
    Astrocyte["Astrocyte"] -->|"contributes to"| SYNAPTIC_DYSFUNCTION
    Class_I_HDACs["Class I HDACs"] -->|"contributes to"| SYNAPTIC_DYSFUNCTION

Outgoing (11)

Target	Relation	Type	Str
Neurodegenerative Diseases	involved_in	disease	0.95
Frontotemporal Dementia	contributes_to	disease	0.95
Alzheimer's Disease	associated_with	disease	0.90
Alzheimer'S Disease	contributes_to	disease	0.90
Cognitive decline	causes	phenotype	0.85
Cognitive Decline	associated_with	phenotype	0.85
Neurodegenerative Diseases	contributes_to	disease	0.85
Sporadic Alzheimer's Disease	associated_with	disease	0.85
Parkinson's Disease Pathology	contributes_to	mechanism	0.85
Alzheimer's disease	associated_with	disease	0.70
AD pathology	causes	disease	0.70

Incoming (63)

Source	Relation	Type	Str
Disease	associated_with	disease	0.95
Neurodegenerative Diseases	associated_with	disease	0.95
Brain Lipid Metabolism	contributes_to	pathway	0.90
Astrocyte	contributes_to	cell_type	0.90
Sporadic Alzheimer's Disease	causes	disease	0.90
Hdac (Class I)	contributes_to	enzyme	0.90
C1q	causes	protein	0.90
SOLUBLE OLIGOMERS	causes	protein	0.90
Amyloid β	causes	protein	0.90
aging	promotes	process	0.90
Alzheimer'S Disease	causes	disease	0.90
Calcium Homeostasis	regulates	process	0.90
Sporadic Alzheimer'S Disease	causes	disease	0.90
Dendritic Spine Morphology Changes	associated_with	phenotype	0.90
AdipoRon	protects_against	drug	0.90
TNF	causes	protein	0.88
IL-6	causes	protein	0.88
IL-1Β	causes	protein	0.88
neuroinflammation	causes	mechanism	0.88
Class I HDACs	contributes_to	enzyme	0.88
α-synuclein	causes	protein	0.85
BDNF	protects_against	protein	0.85
Elevated Cortisol	causes	biomarker	0.85
Pathological Protein Aggregation	contributes_to	mechanism	0.85
Phosphorylated Tau	contributes_to	biomarker	0.85
MAPT	contributes_to	protein	0.85
Gaba Signaling	associated_with	pathway	0.85
epigenetic dysregulation	causes	process	0.85
NRGN	biomarker_for	gene	0.85
SYT1	biomarker_for	gene	0.85
SNAP25	biomarker_for	gene	0.85
GAP43	biomarker_for	gene	0.85
SYP	biomarker_for	gene	0.85
Impaired Cholinergic Signaling	causes	mechanism	0.82
Oligodendrocytes	contributes_to	cell_type	0.80
HISTONE DEACETYLASES	causes	enzyme	0.80
HDAC1	causes	protein	0.80
Apolipoprotein E	modulates	protein	0.80
Neurogranin	biomarker_for	biomarker	0.80
Glutamatergic Transmission	associated_with	pathway	0.80
Microglia Dysfunction	contributes_to	phenotype	0.80
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.80
PSD-95	protects_against	protein	0.80
APOE	contributes_to	protein	0.80
Neuron-Glia Interaction	contributes_to	process	0.80
AMYLOID-Β	causes	protein	0.80
HDACs	causes	enzyme	0.80
Epigenetic Dysregulation	contributes_to	process	0.80
SNAP-25	biomarker_for	protein	0.80
Gene Transcription Impairments	causes	mechanism	0.78

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop optogenetic targeting PV interneurons to restore	0.952	Alzheimer's disease	Circuit-level neural dynamics in neurode
Excitatory Neuron Synaptic Dysfunction and Mitochondrial Str	0.790	neurodegeneration	Cell type vulnerability debate in Alzhei
SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs	0.652	neurodegeneration	What are the specific PTM changes in syn
Dysregulated G3BP1 Signaling Impairs Local Translation in Ne	0.580	neurodegeneration	How do disease-associated mutations in G
TFEB Family-Wide Activation to Restore Lysosomal Networks in	0.000	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (2)

Scientific analyses that reference this entity

Proteomics Differential Expression in AD CSF and Brain Tissue

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.865

Investigate prion-like spreading of tau pathology through connected brain region

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.640

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD	exploratory	Parkinson's disease	0.900	0.00	iPSC-derived dopaminergic neur	proposed	N/A
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells under arsenite	proposed	N/A

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037]	["Musi Nicolas", "Valentine Joseph M", "	Aging cell	2018
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037]	["Musi Nicolas", "Valentine Joseph M", "	Aging cell	2018
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002

Debates (3)

Multi-agent debates referencing this entity

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.73 · 2026-04-22

Which proteins are differentially expressed in AD CSF and brain tissue, and do t

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Is a 12-protein CSF panel superior to existing plasma p-tau217 for clinical AD p

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning SYNAPTIC DYSFUNCTION in their description or question text

No additional research found