protein 1,819 words KG: SOD3PROTEIN
Contents

SOD3 Protein (Extracellular Superoxide Dismutase)

🔬 Protein Info
Gene SymbolSOD3
AliasesEC-SOD
Chromosome4p15.2
Protein TypeGene
Functionis a copper- and zinc-containing enzyme (Cu/ZnSOD) that is secreted into the extracellular space and the extracellular matrix [1].
Primary Expressionneurons, astrocytes, and particularly in vascular endothelial cells - Lungs: Highest expression in lung tissue - Heart
Molecular Weight135 kDa
Amino Acids366 aa
Exons5
GeneCardsSOD3
Human Protein AtlasSOD3
Associated DiseasesAmyotrophic Lateral Sclerosis
InteractionsAPOE, C/EBPβ, ERK1, GSH, HO1, NRF2
KG Connections44 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
Extracellular Matrix Stiffness Modulation
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Extracellular Vesicle Biogenesis Modulation
Score: 0.58

Related Analyses (10)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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