| Gene Symbol | LRRK1 |
| Full Name | Leucine-Rich Repeat Kinase 1 |
| Aliases | Page for LRRK1, Page for LRRK1 Protein |
| Chromosome | 15q26.3 |
| Protein Type | Kinase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various tissues including the brain, with particularly high expression in osteoclasts and neurons |
| Molecular Weight | 230 kDa |
| Amino Acids | 023 aa |
| UniProt ID | [Q8IWU6](https://www.uniprot.org/uniprot/Q8IWU6) |
| Ensembl ID | ENSG00000153902 |
| GeneCards | LRRK1 |
| Human Protein Atlas | LRRK1 |
| Serine/threonine kinase activity | Autophosphorylation and substrate phosphorylation |
| GTPase activity | ROC domain binds and hydrolyzes GTP |
| Associated Diseases | ALS, Parkinson, Parkinson's disease |
| Interactions | AND, App, DYRK1A, EGF, GAIN, LRRK2 |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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