| Gene Symbol | PLK2 |
| Full Name | Polo-Like Kinase 2 |
| Chromosome | 5q12.1 |
| Protein Family | Polo-like kinase (PLK) family |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that plays critical roles in cellular homeostasis, synaptic function, and stress responses. |
| Primary Expression | neuronal tissue and playing essential roles in brain function [@wong2008] |
| Molecular Weight | 71 kDa |
| Amino Acids | 657 aa |
| UniProt ID | Q9NYY3 |
| NCBI Gene ID | 10769 |
| Ensembl ID | ENSG00000145631 |
| GeneCards | PLK2 |
| Human Protein Atlas | PLK2 |
| Autophosphorylation | PLK2 can autophosphorylate itself, which may regulate its activity and stability |
| Associated Diseases | Als, Ischemia, neurodegeneration, Parkinson, Stroke |
| Known Drugs/Compounds | levodopa |
| Interactions | AND, ERK2, NEURODEGENERATION, PARKINSON, SNCA, Α-Synuclein |
| KG Connections | 57 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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