Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PARK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PARK1 |
| Key Genes/Proteins | ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER DISEASE, AND, App, DJ-1 |
| Related Diseases | Alzheimer, Huntington |
| Related Pathways | Alpha-Synuclein |
Knowledge base pages for this entity
graph TD
PARK1["PARK1"]
PARK1 -->|"transports"| Huntington["Huntington"]
PARK1 -->|"transports"| Parkinson["Parkinson"]
PARK1 -->|"causes"| Parkinson_s_disease["Parkinson's disease"]
PARK1 -->|"expressed in"| PARKIN["PARKIN"]
PARK1 -->|"expressed in"| GENES["GENES"]
PARK1 -->|"expressed in"| PARK2["PARK2"]
PARK1 -->|"expressed in"| DJ_1["DJ-1"]
PARK1 -->|"expressed in"| AND["AND"]
PARK7["PARK7"] -->|"expressed in"| PARK1
PARK2 -->|"expressed in"| PARK1
DJ_1 -->|"expressed in"| PARK1
PARKIN -->|"expressed in"| PARK1
HUNTINGTON["HUNTINGTON"] -->|"transports"| PARK1
PARKINSON["PARKINSON"] -->|"transports"| PARK1| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | transports | disease | 0.65 |
| Huntington | transports | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Huntington | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| PARK2 | causes | gene | 0.60 |
| PARK7 | causes | gene | 0.60 |
| Parkinson's disease | causes | disease | 0.60 |
| PARKIN | expressed_in | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| Ubiquitin-Proteasome | associated_with | pathway | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| GENE MUTATIONS | associated_with | gene | 0.60 |
| ALZHEIMER DISEASE | associated_with | gene | 0.60 |
| PARK2 | expressed_in | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| HUNTINGTON | associated_with | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| DJ-1 | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| ALPHA-SYNUCLEIN | expressed_in | gene | 0.60 |
| PARK7 | expressed_in | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 0.60 |
| Alpha-Synuclein | expressed_in | pathway | 0.60 |
| ALZHEIMER | transports | gene | 0.60 |
| Proteasome | associated_with | pathway | 0.60 |
| Ubiquitin-Proteasome | transports | pathway | 0.60 |
| Ubiquitin | transports | protein | 0.60 |
| Proteasome | transports | protein | 0.60 |
| App | transports | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HUNTINGTON | associated_with | gene | 0.60 |
| PARK7 | expressed_in | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PARK2 | expressed_in | gene | 0.60 |
| DJ-1 | expressed_in | gene | 0.60 |
| PARKIN | expressed_in | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| HUNTINGTON | transports | gene | 0.60 |
| PARKINSON | transports | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PARK1 in their description or question text
No additional research found