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gene 1,225 words KG: PARK16
Contents

PARK16 - Parkinson's Disease Locus 16

🧬 Gene Info
Gene SymbolPARK16
Full NameParkinson's Disease Locus 16
Chromosome1q32
Amino Acids220 aa
PathwaysRole of RAB7L1
UniProt IDRAB7L1
NCBI Gene ID493856
Ensembl IDENSG00000109189
GeneCardsPARK16
Human Protein AtlasPARK16
Associated DiseasesParkinson, Parkinson's disease
InteractionsActin, LRRK2, PARKINSON'S DISEASE, RAB10
KG Connections19 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.76Autophagosome Maturation Checkpoint Control
Score: 0.71VCP-Mediated Autophagy Enhancement
Score: 0.59

Related Analyses (13)

TREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · completedGBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completedGut-Brain Axis Therapeutics for AD
neurodegeneration · completedTREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · completed

Related Experiments (30)

TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

See Also (6)

Parkinson Basal Ganglia Circuit
circuit · KG edge: associated_withNeurodegeneration
disease · KG edge: implicated_inrab10 Gene
gene · KG edge: activatesRAB29 — RAS-Related Protein Rab-29
gene · KG edge: associated_withActin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: activates

Knowledge Graph (12 edges)

RAB29 associated_with PARK16
LRRK2 associated_with PARK16
RAB10 activates PARK16
PARK16 activates RAB10
PARK16 associated_with RAB29
PARK16 associated_with LRRK2
LRRK2 expressed_in PARK16
RAB29 expressed_in PARK16
LRRK2 co_expressed_with PARK16
LRRK2 activates PARK16

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