concept

NEUROPEPTIDE Y

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROPEPTIDE Y: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

1Hypotheses

0Analyses

7Outgoing

27Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NEUROPEPTIDE Y

Pathway Diagram

graph TD
    NEUROPEPTIDE_Y[NEUROPEPTIDE Y]
    NEUROPEPTIDE_Y -->|required_for| BDNF_NGFR_signaling[BDNF/NGFR signaling]
    NEUROPEPTIDE_Y -->|released_by| neurons[neurons]
    NEUROPEPTIDE_Y -->|active_in| hippocampus[hippocampus]
    NEUROPEPTIDE_Y -->|released_by| interneurons[interneurons]
    NEUROPEPTIDE_Y -->|active_in| prefrontal_cortex[prefrontal cortex]
    NEUROPEPTIDE_Y -->|released_by| neural_stem_cells[neural stem cells]
    NEUROPEPTIDE_Y -->|released_by| microglia[microglia]
    ABCA7[ABCA7] -->|induces| NEUROPEPTIDE_Y
    depression[depression] -->|disrupts| NEUROPEPTIDE_Y
    BDNF[BDNF] -->|regulates| NEUROPEPTIDE_Y
    Alzheimer_s_disease[Alzheimer's disease] -->|disrupts| NEUROPEPTIDE_Y
    GABRA1[GABRA1] -->|implicated in| NEUROPEPTIDE_Y
    SST[SST] -->|activates| NEUROPEPTIDE_Y
    NMDA_receptor[NMDA receptor] -->|binds| NEUROPEPTIDE_Y

Outgoing (7)

Target	Relation	Type	Str
neurons	released_by	cell_type	0.80
BDNF/NGFR signaling	required_for	pathway	0.80
hippocampus	active_in	brain_region	0.70
neural stem cells	released_by	cell_type	0.60
microglia	released_by	cell_type	0.60
prefrontal cortex	active_in	brain_region	0.60
interneurons	released_by	cell_type	0.60

Incoming (27)

Source	Relation	Type	Str
ABCA7	induces	gene	0.80
BDNF	activates	gene	0.70
Alzheimer's disease	disrupts	disease	0.70
depression	disrupts	disease	0.70
BDNF	regulates	gene	0.70
SNAP25	associated_with	gene	0.60
SST	activates	gene	0.60
MTNR1A	associated_with	gene	0.60
NMDA receptor	binds	receptor	0.60
GABA	regulates	gene	0.60
SST	regulates	gene	0.60
BDNF	biomarker_for	gene	0.60
SST	biomarker_for	gene	0.60
SLC17A7	associated_with	gene	0.60
GABA	biomarker_for	gene	0.60
PVALB	associated_with	gene	0.60
Parkinson's disease	disrupts	disease	0.60
GABRA1	implicated_in	gene	0.60
SST	associated_with	gene	0.60
HCN1	activates	gene	0.60
HCN1	regulates	gene	0.60
BDNF	implicated_in	gene	0.60
HCN1	implicated_in	gene	0.60
schizophrenia	disrupts	disease	0.60
autism	disrupts	disease	0.60
PTSD	disrupts	disease	0.60
neurodegeneration	disrupts	disease	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Neuropeptide Y (NPY) Co-release from PV Interneurons Modulat	0.560	Alzheimer's disease	Closed-loop optogenetic targeting PV int

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEUROPEPTIDE Y in their description or question text

No additional research found