gene

KCNH7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNH7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

23Outgoing

5Incoming

0Experiments

0Debates

Summary

KCNH7: Voltage-gated potassium channel (ERG3) regulating neuronal excitability, pacemaker activity, and implicated in neurodegenerative diseases through ion channel dysfunction

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	KCNH7
Chromosome	2q31.1
Function	is a member of the ether-à-go-go family of voltage-gated potassium channels.
Primary Expression	CNS predominant
Molecular Weight	110 kDa
Amino Acids	964 aa
Exons	15
UniProt ID	Q9NS88
NCBI Gene ID	343472
Ensembl ID	ENSG00000168619
GeneCards	KCNH7
Human Protein Atlas	KCNH7
Associated Diseases	Alzheimer's disease, Parkinson's disease, Epilepsy
Interactions	ACC, Albumin, AND, NEURON, SHANK3, SST
KG Connections	28 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNH7 — AlphaFold Q9NS88 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNH7 Gene

gene · 1986 words

→

Pathway Diagram

graph TD
    KCNH7["KCNH7"]
    Als{"Als"}
    KCNH7 -->|"therapeutic target"| Als
    Tumor{"Tumor"}
    KCNH7 -->|"therapeutic target"| Tumor
    Glioblastoma{"Glioblastoma"}
    KCNH7 -->|"therapeutic target"| Glioblastoma
    GBM["GBM"]
    KCNH7 -->|"associated with"| GBM
    DIAPH3["DIAPH3"]
    KCNH7 -->|"associated with"| DIAPH3
    SYT1["SYT1"]
    KCNH7 -->|"associated with"| SYT1
    neurodegeneration["neurodegeneration"]
    KCNH7 -->|"implicated in"| neurodegeneration
    style KCNH7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (23)

Target	Relation	Type	Str
Autism	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
GBM	associated_with	gene	0.60
DIAPH3	associated_with	gene	0.60
SYT1	associated_with	gene	0.60
SST	inhibits	gene	0.60
AND	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
ACC	interacts_with	gene	0.60
Interneuron	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
Albumin	interacts_with	protein	0.60
Pyramidal	interacts_with	cell_type	0.60
Cortex	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
Interneuron	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
INTERNEURON	inhibits	concept	0.50
INTERNEURONS	inhibits	concept	0.50
Neuron	interacts_with	cell_type	0.50
INTERNEURON	interacts_with	concept	0.50

Incoming (5)

Source	Relation	Type	Str
SST	inhibits	gene	0.60
ACC	interacts_with	gene	0.60
SHANK3	inhibits	gene	0.60
NEURON	inhibits	gene	0.50
AUTISM	inhibits	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNH7 in their description or question text

No additional research found