gene

HEXA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEXA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

4Hypotheses

0Analyses

25Outgoing

8Incoming

0Experiments

0Debates

Summary

Page for HEXA Gene - Hexosaminidase Alpha

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🧬 Gene Info

Gene Symbol	HEXA
Aliases	Page for HEXA Gene
Chromosome	15q24.1
Function	The HEXA gene encodes the alpha subunit of the enzyme β-hexosaminidase A (Hex A), a lysosomal hydrolase essential for the catabolism of GM2 ganglioside and other glycoconjugates containing N-acetylhex
Primary Expression	most tissues with highest levels in:
UniProt ID	P06865
NCBI Gene ID	3073
Ensembl ID	ENSG00000213626
OMIM	272800
GeneCards	HEXA
Human Protein Atlas	HEXA
Associated Diseases	disease
Interactions	DEMENTIA, GBA, NEURON, PARKINSON, PARKINSON'S DISEASE, Rb
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HEXA — AlphaFold P06865 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HEXA Gene - Hexosaminidase Alpha

gene · 916 words

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HEXA (Redirect)

redirect · 648 words

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Pathway Diagram

graph TD
    HEXA["HEXA"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    HEXA -->|"contributes_to"| Amyotrophic_Lateral_Sclerosis
    Huntington{"Huntington"}
    HEXA -->|"contributes_to"| Huntington
    Dementia{"Dementia"}
    HEXA -->|"contributes_to"| Dementia
    Ataxia{"Ataxia"}
    HEXA -->|"contributes_to"| Ataxia
    AND(["AND"])
    HEXA -->|"associated_with"| AND
    C9ORF72(["C9ORF72"])
    HEXA -->|"contributes_to"| C9ORF72
    DEMENTIA(["DEMENTIA"])
    DEMENTIA -.->|"inhibits"| HEXA
    GBA(["GBA"])
    GBA -.->|"inhibits"| HEXA
    GENES(["GENES"])
    GENES -->|"co_discussed"| HEXA
    NEURON(["NEURON"])
    NEURON -.->|"inhibits"| HEXA
    style HEXA fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (25)

Target	Relation	Type	Str
Parkinson	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.65
Huntington	contributes_to	disease	0.65
Dementia	contributes_to	disease	0.65
Ataxia	contributes_to	disease	0.65
HUNTINGTON	contributes_to	gene	0.60
DEMENTIA	contributes_to	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	contributes_to	gene	0.60
Α-Synuclein	inhibits	protein	0.60
C9ORF72	contributes_to	gene	0.60
GBA	associated_with	gene	0.60
DEMENTIA	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
HEXB	associated_with	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
Sphingolipid	inhibits	pathway	0.60
NEURON	associated_with	gene	0.60
Rb	inhibits	protein	0.60
Neuron	associated_with	cell_type	0.60
Neuron	expressed_in	cell_type	0.55
HEXB	co_discussed	gene	0.50
disease	associated_with	disease	0.50

Incoming (8)

Source	Relation	Type	Str
GENES	associated_with	gene	0.60
PARKINSON	inhibits	gene	0.60
GBA	associated_with	gene	0.60
HEXB	associated_with	gene	0.60
GBA	inhibits	gene	0.50
DEMENTIA	inhibits	gene	0.50
GENES	co_discussed	gene	0.50
NEURON	inhibits	gene	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ω-3 Docosahexaenoic Acid (DHA) Epoxide Generation via CYP2J2	0.752	lipidomics	Lipid metabolism dysregulation in Alzhei
C9orf72 Hexanucleotide Repeat Dipeptide Repeat Proteins Inhi	0.738	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
Axonal Transport Defect: C9orf72 hexanucleotide expansion im	0.660	neurodegeneration	What are the neuron-specific effects of
ω-3 Docosahexaenoic Acid (DHA) Metabolism via 15-Lipoxygenas	0.000	lipidomics	Lipid metabolism dysregulation in Alzhei

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HEXA in their description or question text

No additional research found