protein

GASDERMIN D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GASDERMIN D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

35Outgoing

22Incoming

0Experiments

0Debates

Summary

Page for Gasdermin D Protein

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🔬 Protein Info

Gene Symbol	GASDERMIN D
Molecular Weight	52.8 kDa
Amino Acids	487 aa
Pathways	Pyroptosis, Nlrp3 Inflammasome, inflammation, Necroptosis
Associated Diseases	ferroptosis
Interactions	AIM2, ALZHEIMER, CASPASE-1, GASDERMIN, GSDMD, IL-1Β
KG Connections	53 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    GASDERMIN_D["GASDERMIN D"]
    NLRP3["NLRP3"]
    GASDERMIN_D -->|"activates"| NLRP3
    INFLAMMASOME["INFLAMMASOME"]
    GASDERMIN_D -->|"activates"| INFLAMMASOME
    NEUROTOXICITY["NEUROTOXICITY"]
    GASDERMIN_D -->|"activates"| NEUROTOXICITY
    GASDERMIN["GASDERMIN"]
    GASDERMIN_D -->|"activates"| GASDERMIN
    NLRP3["NLRP3"]
    GASDERMIN_D -->|"regulates"| NLRP3
    INFLAMMASOME["INFLAMMASOME"]
    GASDERMIN_D -->|"regulates"| INFLAMMASOME
    Pyroptosis["Pyroptosis"]
    GASDERMIN_D -->|"regulates"| Pyroptosis
    Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    GASDERMIN_D -->|"regulates"| Nlrp3_Inflammasome
    GASDERMIN["GASDERMIN"]
    GASDERMIN_D -->|"regulates"| GASDERMIN
    Proteins["Proteins"]
    GASDERMIN_D -->|"regulates"| Proteins
    TEMPORAL_LOBE["TEMPORAL LOBE"]
    GASDERMIN_D -->|"regulates"| TEMPORAL_LOBE
    CASPASE_1["CASPASE-1"]
    GASDERMIN_D -->|"activates"| CASPASE_1
    inflammation["inflammation"]
    GASDERMIN_D -->|"activates"| inflammation
    ALZHEIMER["ALZHEIMER"]
    GASDERMIN_D -->|"activates"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    GASDERMIN_D -->|"activates"| Alzheimer_S_Disease
    CYTOKINES["CYTOKINES"]
    GASDERMIN_D -->|"activates"| CYTOKINES
    Pyroptosis["Pyroptosis"]
    GASDERMIN_D -->|"activates"| Pyroptosis
    PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
    GASDERMIN_D -->|"activates"| PROINFLAMMATORY_CYTOKINES
    disease["disease"]
    GASDERMIN_D -->|"activates"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    GASDERMIN_D -->|"activates"| ALZHEIMER_S
    apoptosis["apoptosis"]
    GASDERMIN_D -->|"activates"| apoptosis
    Necroptosis["Necroptosis"]
    GASDERMIN_D -->|"activates"| Necroptosis
    Melanoma["Melanoma"]
    GASDERMIN_D -->|"activates"| Melanoma
    atherosclerosis["atherosclerosis"]
    GASDERMIN_D -->|"inhibits"| atherosclerosis
    Pyroptosis["Pyroptosis"]
    GASDERMIN_D -->|"inhibits"| Pyroptosis
    Macrophage["Macrophage"]
    GASDERMIN_D -->|"inhibits"| Macrophage
    MACROPHAGES["MACROPHAGES"]
    GASDERMIN_D -->|"inhibits"| MACROPHAGES
    GASDERMIN["GASDERMIN"]
    GASDERMIN_D -->|"inhibits"| GASDERMIN
    NLRP3["NLRP3"]
    GASDERMIN_D -->|"associated with"| NLRP3
    INFLAMMASOME["INFLAMMASOME"]
    GASDERMIN_D -->|"associated with"| INFLAMMASOME

Outgoing (35)

Target	Relation	Type	Str
Neurotoxicity	mediates	phenotype	0.85
Pyroptosis	inhibits	pathway	0.50
Macrophage	inhibits	cell_type	0.50
MACROPHAGES	inhibits	concept	0.50
atherosclerosis	inhibits	disease	0.50
NLRP3	associated_with	protein	0.50
Nlrp3 Inflammasome	associated_with	pathway	0.50
GASDERMIN	associated_with	gene	0.50
GASDERMIN	inhibits	gene	0.50
CELL DEATH	associated_with	concept	0.50
CYTOKINE	associated_with	concept	0.50
NLRP3	activates	protein	0.50
NEUROTOXICITY	activates	concept	0.50
GASDERMIN	activates	gene	0.50
NLRP3	regulates	protein	0.50
Pyroptosis	regulates	pathway	0.50
Nlrp3 Inflammasome	regulates	pathway	0.50
GASDERMIN	regulates	gene	0.50
Proteins	regulates	protein	0.50
TEMPORAL LOBE	regulates	concept	0.50
CASPASE-1	activates	protein	0.50
inflammation	activates	pathway	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
CYTOKINES	activates	concept	0.50
Pyroptosis	activates	pathway	0.50
PROINFLAMMATORY CYTOKINES	activates	concept	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
apoptosis	activates	process	0.50
Necroptosis	activates	pathway	0.50
Melanoma	activates	disease	0.50
CASPASE-1	associated_with	protein	0.50
ferroptosis	associated_with	phenotype	0.50
Pyroptosis	associated_with	pathway	0.50

Incoming (22)

Source	Relation	Type	Str
NLRP3	interacts_with	gene	0.70
NLRP3	activates	gene	0.70
NLRP3	regulates	gene	0.60
TGM2	associated_with	gene	0.50
GSDMD	associated_with	protein	0.50
BDNF	associated_with	gene	0.50
GSDMD	inhibits	protein	0.50
GFAP	associated_with	gene	0.50
CREB	associated_with	protein	0.50
GPX4	associated_with	gene	0.50
Neurodegeneration	activates	disease	0.50
IL-1Β	activates	protein	0.50
microglia	activates	cell_type	0.50
RIPK1	activates	gene	0.50
MYD88	activates	gene	0.50
INPP5D	activates	gene	0.50
AIM2	activates	gene	0.50
MLKL	activates	gene	0.50
GSDMD	regulates	protein	0.50
IL-1Β	associated_with	protein	0.50
ZBP1	activates	gene	0.50
GSDMD	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GASDERMIN D in their description or question text

No additional research found