gene

GNAQ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNAQ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

11Outgoing

11Incoming

0Experiments

0Debates

Summary

GNAQ is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Cancer, Carcinoma. Connected to 23 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GNAQ
Full Name	G Protein Subunit Alpha Q
Chromosome	9q21.13
Function	The GNAQ protein is involved in transmitting signals from G protein-coupled receptors (GPCRs) on the cell surface to intracellular effector proteins.
Primary Expression	the central nervous system and is particularly important for neuronal signaling, synaptic plasticity, and cellular responses to neurotransmitters and
Pathways	Akt, Pi3K
UniProt ID	[P50148](https://www.uniprot.org/uniprot/P50148)
Ensembl ID	ENSG00000156052
GeneCards	GNAQ
Human Protein Atlas	GNAQ
Calcium signaling	Modulation of neuronal excitability and synaptic transmission
PKC activation	Regulation of ion channel function and gene expression
Cytoskeletal dynamics	Control of neuronal morphology and plasticity
Associated Diseases	neurodegeneration
Interactions	AKT, BRAF, ERK, ERK1, GENES, GNA11
KG Connections	22 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GNAQ Gene

gene · 1049 words

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Pathway Diagram

graph TD
    GNAQ["GNAQ"]
    Als{"Als"}
    GNAQ -->|"activates"| Als
    Ms{"Ms"}
    GNAQ -->|"activates"| Ms
    GNAQ -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    GNAQ -->|"therapeutic target"| Cancer
    Carcinoma{"Carcinoma"}
    GNAQ -->|"therapeutic target"| Carcinoma
    STX17["STX17"]
    GNAQ -->|"activates"| STX17
    GNA11["GNA11"]
    GNAQ -->|"activates"| GNA11
    AKT["AKT"]
    GNAQ -->|"activates"| AKT
    Akt(["Akt"])
    GNAQ -->|"activates"| Akt
    Pi3K(["Pi3K"])
    GNAQ -->|"activates"| Pi3K
    Mapk(["Mapk"])
    GNAQ -->|"associated with"| Mapk
    neurodegeneration["neurodegeneration"]
    GNAQ -->|"implicated in"| neurodegeneration
    BRAF["BRAF"]
    BRAF -->|"activates"| GNAQ
    KRAS["KRAS"]
    KRAS -->|"activates"| GNAQ
    ERK["ERK"]
    ERK -->|"activates"| GNAQ
    PI3K["PI3K"]
    PI3K -->|"activates"| GNAQ
    GENES["GENES"]
    GENES -->|"activates"| GNAQ
    ERK1["ERK1"]
    ERK1 -->|"activates"| GNAQ
    FYN["FYN"]
    FYN -->|"associated with"| GNAQ
    MAPK3["MAPK3"]
    MAPK3 -->|"associated with"| GNAQ
    PAK1["PAK1"]
    PAK1 -->|"associated with"| GNAQ
    CDK2["CDK2"]
    CDK2 -->|"associated with"| GNAQ
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"associated with"| GNAQ
    style GNAQ fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Als	activates	disease	0.65
Ms	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Mapk	associated_with	pathway	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
STX17	activates	gene	0.60
GNA11	activates	gene	0.60
AKT	activates	gene	0.60

Incoming (11)

Source	Relation	Type	Str
BRAF	activates	gene	0.60
PI3K	activates	gene	0.60
ERK1	activates	gene	0.60
KRAS	activates	gene	0.60
ERK	activates	gene	0.60
GENES	activates	gene	0.60
FYN	associated_with	gene	0.60
MAPK3	associated_with	gene	0.60
PAK1	associated_with	gene	0.60
CDK2	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GNAQ in their description or question text

No additional research found