gene

ERP57

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERP57: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

19Outgoing

8Incoming

0Experiments

0Debates

Summary

ERP57 (PDIA3) — Protein Disulfide Isomerase Family A Member 3

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🧬 Gene Info

Gene Symbol	ERP57
Aliases	Protein Disulfide Isomerase Family A Member 3
Chromosome	15q15.3
Protein Family	PDI family
Protein Type	Chaperone
Function	is a critical endoplasmic reticulum (ER) chaperone protein that plays essential roles in protein folding, disulfide bond formation, and ER stress responses.
Molecular Weight	57 kDa
Amino Acids	505 aa
Exons	13
Pathways	Mapk, Mtor, Pi3K/Akt
UniProt ID	[P30101](https://www.uniprot.org/uniprot/P30101)
Ensembl ID	ENSG00000123131
OMIM	602046
GeneCards	ERP57
Human Protein Atlas	ERP57
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, AUTOPHAGY, CANCER, INFLAMMATION, PDIA3, ROS
KG Connections	27 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ERP57 (PDIA3) — Protein Disulfide Isomerase Family A Member 3

gene · 3072 words

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Pathway Diagram

graph TD
    ERP57["ERP57"]
    Als{"Als"}
    ERP57 -->|"expressed in"| Als
    PDIA3["PDIA3"]
    ERP57 -->|"activates"| PDIA3
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    ERP57 -->|"activates"| Unfolded_Protein_Response
    Autophagy(["Autophagy"])
    ERP57 -->|"expressed in"| Autophagy
    neurodegeneration["neurodegeneration"]
    ERP57 -->|"implicated in"| neurodegeneration
    style ERP57 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Autophagy	activates	pathway	0.60
Mtor	regulates	pathway	0.60
Apoptosis	activates	pathway	0.60
Mapk	regulates	pathway	0.60
Necroptosis	activates	pathway	0.60
CANCER	activates	gene	0.60
PDIA3	activates	gene	0.60
MYC	regulates	gene	0.60
AKT	regulates	gene	0.60
SRC	regulates	gene	0.60
MTOR	regulates	gene	0.60
Unfolded Protein Response	activates	pathway	0.60
Pi3K/Akt	regulates	pathway	0.60
Autophagy	expressed_in	pathway	0.60

Incoming (8)

Source	Relation	Type	Str
PI3K	regulates	gene	0.60
BIP	regulates	gene	0.60
ATF2	regulates	gene	0.60
ROS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
RIP1	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERP57 in their description or question text

No additional research found