gene 3,072 words KG: ERP57
Contents

ERP57 (PDIA3) — Protein Disulfide Isomerase Family A Member 3

🧬 Gene Info
Gene SymbolERP57
AliasesProtein Disulfide Isomerase Family A Member 3
Chromosome15q15.3
Protein FamilyPDI family
Protein TypeChaperone
Functionis a critical endoplasmic reticulum (ER) chaperone protein that plays essential roles in protein folding, disulfide bond formation, and ER stress responses.
Molecular Weight57 kDa
Amino Acids505 aa
Exons13
PathwaysMapk, Mtor, Pi3K/Akt
UniProt ID[P30101](https://www.uniprot.org/uniprot/P30101)
Ensembl IDENSG00000123131
OMIM602046
GeneCardsERP57
Human Protein AtlasERP57
Associated Diseasesneurodegeneration
InteractionsAPOPTOSIS, AUTOPHAGY, CANCER, INFLAMMATION, PDIA3, ROS
KG Connections27 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (2)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (13)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
necroptosis
general · KG edge: activates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

ERP57 activates PDIA3
PI3K regulates ERP57
BIP regulates ERP57
ATF2 regulates ERP57
ERP57 regulates MYC
ERP57 regulates AKT
ERP57 regulates SRC
ERP57 regulates MTOR
ERP57 expressed_in Als
ERP57 activates Unfolded Protein Response

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