gene

CYP7B1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP7B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

27Outgoing

12Incoming

0Experiments

0Debates

Summary

Page for CYP7B1 Gene - Hereditary Spastic Paraplegia 5

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🧬 Gene Info

Gene Symbol	CYP7B1
Full Name	Cytochrome P450 7B1 (Oxysterol 7-alpha-hydroxylase)
Aliases	Page for CYP7B1 Gene, Page for CYP7B1 Protein
Chromosome	8q12.3
Function	Cholesterol to 7-alpha-hydroxycholesterol: Rate-limiting step in bile acid synthesis
Primary Expression	Liver, Brain, Kidney, Testis, Spinal cord
Molecular Weight	58 kDa
Pathways	Cholesterol, Lipid Metabolism
UniProt ID	O76074
NCBI Gene ID	9420
Ensembl ID	ENSG00000172817
OMIM	603711
GeneCards	CYP7B1
Human Protein Atlas	CYP7B1
Associated Diseases	Alzheimer
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, C6, CYP27A1, CYP46A1
KG Connections	39 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CYP7B1 — AlphaFold O76074 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CYP7B1 Gene - Hereditary Spastic Paraplegia 5

gene · 672 words

→

CYP7B1 Protein - Oxysterol 7-alpha-hydroxylase

protein · 641 words

→

Pathway Diagram

graph TD
    CYP7B1["CYP7B1"]
    Alzheimer["Alzheimer"]
    CYP7B1 -->|"therapeutic target"| Alzheimer
    Alzheimer["Alzheimer"]
    CYP7B1 -->|"activates"| Alzheimer
    Tumor["Tumor"]
    CYP7B1 -->|"activates"| Tumor
    TNF["TNF"]
    CYP7B1 -->|"therapeutic target"| TNF
    GSH["GSH"]
    CYP7B1 -->|"therapeutic target"| GSH
    CYP46A1["CYP46A1"]
    CYP7B1 -->|"inhibits"| CYP46A1
    IL_6["IL-6"]
    CYP7B1 -->|"therapeutic target"| IL_6
    Lipid_Metabolism["Lipid Metabolism"]
    CYP7B1 -->|"therapeutic target"| Lipid_Metabolism
    Cholesterol["Cholesterol"]
    CYP7B1 -->|"inhibits"| Cholesterol
    TNF["TNF"]
    CYP7B1 -->|"activates"| TNF
    ALZHEIMER["ALZHEIMER"]
    CYP7B1 -->|"activates"| ALZHEIMER
    ROS["ROS"]
    CYP7B1 -->|"activates"| ROS
    IL_6["IL-6"]
    CYP7B1 -->|"activates"| IL_6
    IL_17["IL-17"]
    CYP7B1 -->|"activates"| IL_17
    AND["AND"]
    CYP7B1 -->|"inhibits"| AND
    GSH["GSH"]
    CYP7B1 -->|"activates"| GSH
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    CYP7B1 -->|"activates"| ALZHEIMER_S_DISEASE
    Lipid_Metabolism["Lipid Metabolism"]
    CYP7B1 -->|"activates"| Lipid_Metabolism
    ROS["ROS"]
    ROS -->|"therapeutic target"| CYP7B1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"therapeutic target"| CYP7B1
    IL_17["IL-17"]
    IL_17 -->|"therapeutic target"| CYP7B1
    neurodegeneration["neurodegeneration"]
    CYP7B1 -->|"implicated in"| neurodegeneration

Outgoing (27)

Target	Relation	Type	Str
Alzheimer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	activates	disease	0.65
Interleukin	therapeutic_target	protein	0.60
Il-1	therapeutic_target	protein	0.60
Alzheimer	associated_with	disease	0.60
neurons	expressed_in	cell_type	0.60
TNF	therapeutic_target	gene	0.60
CYP46A1	inhibits	gene	0.60
TNF	activates	gene	0.60
Rb	therapeutic_target	protein	0.60
GSH	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Cholesterol	inhibits	pathway	0.60
ALZHEIMER	activates	gene	0.60
ROS	activates	gene	0.60
IL-6	activates	gene	0.60
IL-17	activates	gene	0.60
AND	inhibits	gene	0.60
GSH	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
Lipid Metabolism	activates	pathway	0.60
IL-17	therapeutic_target	gene	0.60
ROS	therapeutic_target	gene	0.60
TNF	co_expressed_with	gene	0.50
Cholesterol	activates	pathway	0.50

Incoming (12)

Source	Relation	Type	Str
GSH	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
C6	activates	gene	0.60
CYP27A1	interacts_with	gene	0.60
CYP27A1	expressed_in	gene	0.60
CYP27A1	regulates	gene	0.60
CYP46A1	regulates	gene	0.60
CYP46A1	interacts_with	gene	0.60
ROS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
IL-17	therapeutic_target	gene	0.60
CYP46A1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CYP7B1 in their description or question text

No additional research found