| Gene Symbol | SLC6A1 |
| Chromosome | 3p25.3 |
| Protein Type | Gene |
| Function | inhibitory neurotransmission and implicated in epilepsy |
| Primary Expression | Brain (neurons and astrocytes), peripheral tissues at low levels |
| Molecular Weight | 67 kDa |
| Amino Acids | 599 aa |
| Exons | 16 |
| UniProt ID | P30531 |
| OMIM | 137165 |
| GeneCards | SLC6A1 |
| Human Protein Atlas | SLC6A1 |
| Sodium binding sites | Two high-affinity Na⁺ binding sites (Na1 and Na2) required for transport |
| Chloride binding site | Cl⁻ binding is required for transport activity and affects substrate affinity |
| Functional unit | GAT1 forms a homodimer in the plasma membrane; dimerization is required for functional transport |
| Associated Diseases | Alzheimer |
| Interactions | ABCB1, APOD, CALM1, COL4A1, GABA, GENES |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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