| Gene Symbol | C6 |
| Full Name | Complement Component 6 |
| Chromosome | 5p13.1 |
| Protein Family | Complement system (terminal pathway) |
| Function | C6 functions exclusively in the terminal complement pathway[@structure2015][@complement2018]: |
| Subcellular Localization | Plasma, cell membrane |
| Molecular Weight | 120 kDa |
| Amino Acids | 922 aa |
| UniProt ID | P13671 |
| GeneCards | C6 |
| Human Protein Atlas | C6 |
| N-terminal domain | Contains cysteine-rich repeats (MCP/CD46-like) |
| Thrombospondin type I repeats | Protein-protein interaction motifs |
| C-terminal domain | Critical for complex formation with C5b-7 |
| Disulfide bonds | Stabilize protein structure |
| Associated Diseases | neurodegeneration |
| Interactions | C3, CYP46A1, CYP7B1, SARM1 |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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