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gene 988 words KG: ASH1L
Contents

ASH1L

🧬 Gene Info
Gene SymbolASH1L
Chromosome1q22
Protein TypeTransferase
FunctionHistone H3K36 methyltransferase
Amino Acids2964 aa
Exons28
PathwaysMapk, Mismatch Repair, Wnt, Epigenetic
Ensembl IDENSG00000116539
GeneCardsASH1L
Human Protein AtlasASH1L
Associated DiseasesFibrosis, Tourette syndrome
InteractionsASH1L-AS1, MMP, NME1, Ras
KG Connections30 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (11)

KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE-TREM2 Interaction Modulation
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-mediated microglial tau clearance enhancement
Score: 0.62SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.54

Related Analyses (2)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: expressed_inEpigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: associated_withGenes
index · KG edge: contributes_toARID1A
gene · KG edge: contributes_toEP300 Gene
gene · KG edge: contributes_to

Knowledge Graph (12 edges)

ASH1L activates NME1
ASH1L inhibits MMP
ASH1L associated_with Tourette syndrome
ASH1L-AS1 interacts_with ASH1L
ASH1L upregulates STAC2
ASH1L inhibits osteoclastogenesis
ASH1L inhibits miR-let-7b
ASH1L catalyzes H3K36me
ASH1L catalyzes H3K4me
ASH1L upregulates IGF-2

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