concept

T3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about T3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

18Hypotheses

0Analyses

12Outgoing

2Incoming

2Experiments

0Debates

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💡 Concept Info

Name	T3
Key Genes/Proteins	AKT, BAX, BCL-2, MCT8, MTOR
Related Diseases	Alzheimer's disease, brown adipose tissue activation, mitochondrial biogenesis, mitophagy
Linked Hypotheses	18 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    T3["T3"]
    T3 -->|"activates"| brown_adipose_tissue_activatio["brown adipose tissue activation"]
    T3 -->|"inhibits"| BAX["BAX"]
    T3 -->|"upregulates"| BCL_2["BCL-2"]
    T3 -->|"activates"| mitochondrial_biogenesis["mitochondrial biogenesis"]
    T3 -->|"activates"| mitophagy["mitophagy"]
    T3 -->|"activates"| AKT["AKT"]
    T3 -->|"inhibits"| neuroinflammation["neuroinflammation"]
    MCT8["MCT8"] -->|"binds_to"| T3

Outgoing (12)

Target	Relation	Type	Str
brown adipose tissue activation	activates	phenotype	0.95
BCL-2	upregulates	protein	0.95
BAX	downregulates	protein	0.95
BAX	inhibits	protein	0.95
AKT	activates	protein	0.90
neuroinflammation	inhibits	process	0.90
mitochondrial biogenesis	activates	phenotype	0.90
mitophagy	activates	phenotype	0.90
AKT	phosphorylates	protein	0.90
Alzheimer's disease	treats	disease	0.85
Alzheimer's disease	protects_against	disease	0.85
MTOR	inhibits	protein	0.80

Incoming (2)

Source	Relation	Type	Str
MCT8	binds_to	protein	0.60
MCT8	interacts_with	protein	0.60

Targeting Hypotheses (18)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.777	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.776	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.764	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.738	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Metabolic Inflexibility Precedes Transcriptional Reprogrammi	0.735	neurodegeneration	What is the optimal therapeutic window f

ATF4-DDIT3 stress signaling indirectly represses MAPT transc	0.624	neurodegeneration	Which specific transcription factors med
PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-In	0.618	neurodegeneration	How do perivascular cells specifically r
SIRT3 loss creates a mitochondrial acetylation-stress loop t	0.560	neurodegeneration	What mechanisms drive the self-amplifyin
Astrocytic SPP1 Modulation Through STAT3-Dependent Transcrip	0.551	neuroinflammation	What molecular mechanisms mediate SPP1-i
CNTF-JAK/STAT3 Reprogramming of Trained Microglia to Neuropr	0.547	neuroinflammation	What specific astrocyte-derived factors
Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complem	0.540	neuroinflammation	How does sevoflurane-induced NF-κB activ
SIRT3 gates microglial surveillance versus primed metabolism	0.482	neuroinflammation	Do microglia actually switch between gly
DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Sca	0.460	neurodegeneration	Investigate mechanisms of epigenetic rep
Astrocytic SPP1 Modulation via STAT3-Dependent Transcription	0.459	neuroinflammation	What molecular mechanisms mediate SPP1-i
GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ	0.454	lipidomics	Lipid metabolism dysregulation in Alzhei
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r
STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine	0.347	immunomics	Systemic immune profiling in neurodegene
SIRT3 Mitochondrial Activation to Counter Hub-Specific Energ	0.344	connectomics	Human connectome alterations in Alzheime

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD	exploratory	Parkinson's disease	0.900	0.00	iPSC-derived dopaminergic neur	proposed	N/A
bEV isolation and LPS quantification from human samples	clinical	Alzheimer's disease	0.800	0.00	human patients	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730]	Zhang Y, Jiang H, Zhang F, Liao J	Neural regeneration research	2026	0
The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859]	Qi L, Yi J, Shen Y, Jiang H, Yao X et al	Biochem Pharmacol	2026	0
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004]	Zhang H, Xiao J, Yi Y, Chen B, Lv W et a	Phytomedicine	2026	0
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005]	You T, Dai B, Ding X, He Z, Peng J et al	Phytomedicine	2026	0
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026	0
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899]	Yuanyuan Fang; Mengqiu Deng; Kesheng Hua	Cell communication and signali	2026	0
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653]	Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y	Journal of diabetes	2026	0
Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101]	Cheng YL, Su MS, Liao CC, Chang TW, Hsie	Journal of microbiology, immun	2026	0
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436]	Shan C, Szili-Torok T, Yue G, Zhang L, M	Phytomedicine : international	2026	0
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550]	["Gao L", "Shen J", "Gao J", "Li T", "Ya	Antioxidants (Basel, Switzerla	2026	0
Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627]	El-Mahrouk SR, El-Kadi AOS	Archives of toxicology	2025	0
Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796]	Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu	Journal of neuroinflammation	2025	0
Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261]	Yang R, Meng X, Zhao W, Xu SQ, Wang SY,	Bioorganic chemistry	2025	0
Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458]	Pradeepkiran JA, Kshirsagar S, Alvir RV,	Biochimica et biophysica acta.	2025	0
The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632]	Wang H, Liu J, Tian YR, Zhu F, Li H	Journal of Alzheimer's disease	2025	0
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024	0
Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in [PMID:38412923]	["Zhang Tian-Ci", "Lin Yi-Can", "Sun Nin	Neurochemistry international	2024	0
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024	0
Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492]	Unknown	Int J Mol Sci	2023	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning T3 in their description or question text

ATF4-DDIT3 stress signaling indirectly represses MAPT transcription during prote

Score: 0.624 · neurodegeneration · 2026-04-25

Integrated stress response factors redirect transcription and chromatin regulation away from tau expression during acute

PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-Induced SPP1 Upregulat

Score: 0.618 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The proposed PDGF-BB/PDGFRβ/STAT3 signaling axis represents a complex intercellul

SIRT3 loss creates a mitochondrial acetylation-stress loop that weakens antioxid

Score: 0.560 · neurodegeneration · 2026-04-25

Declining SIRT3 activity leaves SOD2, IDH2, and permeability-transition regulators hyperacetylated, reducing mitochondri

Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control

Score: 0.551 · neuroinflammation · 2026-04-20

## Mechanistic Overview Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control starts from the claim

CNTF-JAK/STAT3 Reprogramming of Trained Microglia to Neuroprotective State

Score: 0.547 · neuroinflammation · 2026-04-26

Astrocyte-derived CNTF binds CNTFRα-GP130-LIFRβ receptor complex on microglia, activating JAK1/2 → STAT3 phosphorylation

Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complement Translocation

Score: 0.540 · neuroinflammation · 2026-04-21

## Mechanistic Overview Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complement Translocation starts from the cl

SIRT3 gates microglial surveillance versus primed metabolism through mitochondri

Score: 0.482 · neuroinflammation · 2026-04-21

## Mechanistic Overview SIRT3 gates microglial surveillance versus primed metabolism through mitochondrial deacetylation

DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Scars' at Polycomb Targ

Score: 0.460 · neurodegeneration · 2026-04-21

## Mechanistic Overview DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Scars' at Polycomb Targets starts from

Astrocytic SPP1 Modulation via STAT3-Dependent Transcriptional Control

Score: 0.459 · neuroinflammation · 2026-04-21

## Mechanistic Overview Astrocytic SPP1 Modulation via STAT3-Dependent Transcriptional Control starts from the claim tha

GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ Oligomerization See

Score: 0.454 · lipidomics · 2026-04-25

GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ Oligomerization Seeds

RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivasc

Score: 0.442 · neurodegeneration · 2026-04-22

## Mechanistic Overview RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivascular Fibroblasts

STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory

Score: 0.347 · immunomics · 2026-04-25

STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory

SIRT3 Mitochondrial Activation to Counter Hub-Specific Energetic Vulnerability

Score: 0.344 · connectomics · 2026-04-25

SIRT3 Mitochondrial Activation to Counter Hub-Specific Energetic Vulnerability

T3

Understanding Entity Pages

Wiki Pages (20)

SLC30A3 — Solute Carrier Family 30 Member 3 (ZnT3)

NMNAT3 — Nicotinamide Mononucleotide Adenylyltransferase 3

NFAT3 Gene

SLC22A3 — Solute Carrier Family 22 Member 3 (OCT3)

WNT3 Gene

CST3 Gene - Cystatin C

GALNT3 — Polypeptide N-acetylgalactosaminyltransferase 3

FLT3/FLT3L Cytokine Therapy for Neurodegeneration

TET3 Gene

CHOP Protein (DDIT3)

STAT3 Gene

GABA Transporter 3 (GAT3)

SIRT3 Protein - Mitochondrial Sirtuin

DNMT3B Protein

SYT3 Gene

NMNAT3 Protein

NT3 Gene

MT3

VGLUT3 Gene

NFAT3 Protein

Pathway Diagram

Outgoing (12)

Incoming (2)

Targeting Hypotheses (18)

Mentioning Analyses (0)

Experiments (2)

Related Papers (20)

Debates (0)

Related Research

ATF4-DDIT3 stress signaling indirectly represses MAPT transcription during prote

PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-Induced SPP1 Upregulat

SIRT3 loss creates a mitochondrial acetylation-stress loop that weakens antioxid

Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control

CNTF-JAK/STAT3 Reprogramming of Trained Microglia to Neuroprotective State

Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complement Translocation

SIRT3 gates microglial surveillance versus primed metabolism through mitochondri

DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Scars' at Polycomb Targ

Astrocytic SPP1 Modulation via STAT3-Dependent Transcriptional Control

GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ Oligomerization See

RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivasc

STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory

SIRT3 Mitochondrial Activation to Counter Hub-Specific Energetic Vulnerability