gene 1,439 words KG: GAT3
Contents

GABA Transporter 3 (GAT3)

🧬 Gene Info
Gene SymbolSLC6A11
Full NameSolute Carrier Family 11 Member 11 (GABA Transporter 3)
AliasesGAT3
Chromosome3p25.3
Protein TypeTransporter
Functionis a sodium-dependent GABA transporter belonging to the SLC6A family (neurotransmitter symporters).
Primary Expressionglial cells, particularly astrocytes, where it plays a crucial role in maintaining extracellular and
Amino Acids583 aa
Gene TypeProtein Coding
UniProt IDP48066
NCBI Gene ID6538
Ensembl IDENSG00000137914
GeneCardsSLC6A11
Human Protein AtlasSLC6A11
Associated Diseasesneurodegeneration
InteractionsGAT1, IRF3, STING
KG Connections4 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Migraine Cortical Hyperexcitability and Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (4)

Neurodegeneration
disease · KG edge: implicated_in
GABA Transporter 1
gene · KG edge: activates
IRF3 Gene
gene · KG edge: activates
STING Gene
gene · KG edge: activates

Knowledge Graph (4 edges)

GAT3 activates GAT1
GAT3 activates IRF3
GAT3 activates STING
GAT3 activates Ms

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