gene 1,193 words KG: NT3
Contents

NT3 Gene

🧬 Gene Info
Gene SymbolNT3
Full NameNeurotrophin 3
Chromosome12p13.31
Protein FamilyNeurotrophin
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe developing and adult CNS: - Hippocampus: Highest expression in dentate gyrus and CA3 region - Cerebral cortex
Amino Acids119 aa
PathwaysPI3K, mTOR, mtor, MAPK
UniProt ID[P20783](https://www.uniprot.org/uniprot/P20783)
Ensembl IDENSG00000185652
GeneCardsNT3
Human Protein AtlasNT3
Associated Diseasesneurodegeneration
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND, APP
KG Connections25 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.94
APOE-Dependent Autophagy Restoration
Score: 0.86
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

NeuRon Therapeutics
company · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Neprilysin (NEP)
entity · KG edge: activates
SIRT1 (Redirect)
redirect · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates

Knowledge Graph (12 edges)

TRKB activates NT3
NT3 activates BDNF
NT4 activates NT3
BDNF activates NT3
MECP2 activates NT3
NT3 activates NEPRILYSIN
NT3 activates SIRT1
NT3 activates TRKB
NT3 activates APP
NT3 activates Als

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