gene 2,882 words KG: NMNAT3
Contents

NMNAT3 — Nicotinamide Mononucleotide Adenylyltransferase 3

🧬 Gene Info
Gene SymbolNMNAT3
Full NameNicotinamide Mononucleotide Adenylyltransferase 3
Chromosome3q23
Protein TypeEnzyme
Functionis a mitochondrial enzyme critical for NAD+ biosynthesis in mammalian cells.
Primary ExpressionHeart, liver, skeletal muscle, brain
Subcellular Localizationthe mitochondrial matrix where it catalyzes the conversion of nicotinamide mononucleotide (NMN) to NAD+ [@nmnat3_mito_20
Molecular Weight31 kDa
Amino Acids30 aa
UniProt IDQ9H5H4
NCBI Gene ID107150
Ensembl IDENSG00000163644
OMIM608710
GeneCardsNMNAT3
Human Protein AtlasNMNAT3
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

APOE-Dependent Autophagy Restoration
Score: 0.88
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53

Related Analyses (6)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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