concept

PTPRZ1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTPRZ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

30Outgoing

13Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PTPRZ1
Key Genes/Proteins	AKT, AND, ASTROCYTE, ASTROCYTES, DEPRESSION, GBM
Related Diseases	Aging, Als, Autoimmune, Depression, Glioblastoma
Related Pathways	Akt, Blood-Brain Barrier

Pathway Diagram

graph TD
    PTPRZ1["PTPRZ1"]
    PTPRZ1 -->|"activates"| AKT["AKT"]
    PTPRZ1 -->|"interacts"| MET["MET"]
    PTPRZ1 -->|"activates"| Lymphoma["Lymphoma"]
    PTPRZ1 -->|"activates"| Ms["Ms"]
    PTPRZ1 -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    PTPRZ1 -->|"activates"| Autoimmune["Autoimmune"]
    PTPRZ1 -->|"regulates"| Tumor["Tumor"]
    PTPRZ1 -.biomarker for.-> Glioblastoma["Glioblastoma"]
    PTPRZ1 -->|"target for"| Aging["Aging"]
    PTN["PTN"] -->|"interacts"| PTPRZ1
    ASTROCYTES["ASTROCYTES"] -->|"activates"| PTPRZ1
    AKT -->|"activates"| PTPRZ1
    STAT3["STAT3"] -->|"regulates"| PTPRZ1
    MET -->|"regulates"| PTPRZ1
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"target for"| PTPRZ1
    TP53["TP53"] -->|"implicated in"| PTPRZ1

Outgoing (30)

Target	Relation	Type	Str
MET	interacts_with	protein	0.70
AKT	activates	protein	0.70
Depression	activates	disease	0.65
Lymphoma	activates	disease	0.65
Ms	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Autoimmune	activates	disease	0.65
Tumor	regulates	disease	0.65
Glioblastoma	biomarker_for	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioma	therapeutic_target	disease	0.65
Akt	therapeutic_target	pathway	0.60
Neurogenesis	activates	pathway	0.60
Akt	activates	pathway	0.60
GBM	biomarker_for	gene	0.60
TP53	associated_with	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
MET	associated_with	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
ASTROCYTE	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60
PTN	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
oxidative stress response	participates_in	pathway	0.60
DEPRESSION	activates	gene	0.60
ASTROCYTES	inhibits	gene	0.60

Incoming (13)

Source	Relation	Type	Str
PTN	interacts_with	protein	0.70
STAT3	regulates	gene	0.60
MET	regulates	gene	0.60
PTN	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
AND	inhibits	gene	0.60
ASTROCYTES	activates	gene	0.60
AKT	activates	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
PTN	activates	gene	0.60
MET	associated_with	gene	0.60
TP53	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTPRZ1 in their description or question text

No additional research found