| Gene Symbol | ULK1 |
| Chromosome | 2q24 |
| Protein Family | Ser/Thr kinase (ULK family) |
| Protein Type | Kinase |
| Target Class | Kinase |
| Function | ULK1 is the initiating kinase for autophagy |
| Mechanism of Action | Small molecule activators or inhibitors of ULK1 kinase activity to modulate autophagy |
| Subcellular Localization | Cytoplasm, autophagosome |
| Druggability | Low (0.42) |
| Clinical Stage | Phase I |
| Molecular Weight | ~1,050 amino acids (~112 kDa) |
| Amino Acids | 050 aa |
| Pathways | AUTOPHAGY, Autophagy, Cell Cycle, Chaperone, Differentiation |
| UniProt ID | Q8N448 |
| GeneCards | ULK1 |
| Human Protein Atlas | ULK1 |
| Associated Diseases | AD, Aging, ALI, Als, ALZHEIMER |
| Known Drugs/Compounds | ALT001, echinacoside, metformin, rapamycin, RAPAMYCIN, Shikonin |
| Interactions | 14-3-3, 4E-BP1, ABCA1, ABCG1, ACAT1, ACC |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | TFEB-Independent Autophagy Bypass |
| KG Connections | 2411 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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