Contents

PLP1 Protein

🔬 Protein Info

Gene Symbol	PLP1
Protein Family	Proteolipid protein family
Function	PLP1 is essential for multiple aspects of CNS myelination:
Primary Expression	CNS (not PNS)
Subcellular Localization	Myelin sheath, oligodendrocyte plasma membrane
Molecular Weight	30 kDa
Amino Acids	35 aa
Pathways	Phagocytosis
UniProt ID	[P60228](https://www.uniprot.org/uniprot/P60228)
GeneCards	PLP1
Human Protein Atlas	PLP1
PLP1 (276 aa)	Full-length isoform
DM20 (241 aa)	Lacks 35 amino acids (exon 2B), expressed during early development
Myelin formation	Major structural protein of CNS myelin[@greer2007]
Myelin compaction	Helps form the intraperiod line
Associated Diseases	ALS, Alzheimer, dementia, Ms, myelin dysfunction, Parkinson
Known Drugs/Compounds	CURCUMIN, RESVERATROL
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND, APOE, App
KG Connections	207 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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