| Gene Symbol | CATHEPSINS |
| Subcellular Localization | ** | Lysosomes, secreted | |
| Pathways | Oxidative Stress, Mapk, Sod1, Lipid Metabolism, Apoptosis |
| GeneCards | CATHEPSINS |
| Human Protein Atlas | CATHEPSINS |
| Active site | Cys139, His299, Asn319 (catalytic triad) |
| Specificity pocket | S2 pocket prefers hydrophobic residues |
| Occluding loop | Unique among cathepsins, affects substrate access |
| Invariant chain (CD74) | Enables MHC class II antigen presentation |
| Elastin | Elastic fiber degradation |
| Collagen types I-IV | Extracellular matrix remodeling |
| Fibronectin | Matrix component cleavage |
| Cytokines | Processing and activation |
| Associated Diseases | neurodegeneration |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta, APOE, APOPTOSIS |
| KG Connections | 73 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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