| Gene Symbol | CTSZ |
| Full Name | Cathepsin Z |
| Aliases | Page for CTSZ Gene |
| Chromosome | 20q13.12 |
| Protein Type | Protease |
| Function | , also known as Cathepsin X, is a unique lysosomal cysteine protease that possesses both endopeptidase and carboxypeptidase activities[@bhling2004] |
| Primary Expression | AD brain and localizes to amyloid plaques[@wang2012] 2 |
| Pathways | Autophagy, Immune Response, Mitophagy, lysosomal function |
| UniProt ID | [O60840](https://www.uniprot.org/uniprot/O60840) |
| Ensembl ID | ENSG00000021574 |
| OMIM | 602088 |
| GeneCards | CTSZ |
| Human Protein Atlas | CTSZ |
| Lysosomal Protein Degradation | Central role in cellular protein turnover |
| Immune Regulation | Modulates T-cell function and macrophage activity |
| Associated Diseases | neurodegeneration |
| Interactions | ALZHEIMER, AMYLOID, Amyloid Beta, AUTOPHAGY, Aβ, CATHEPSINS |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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